HU MD Proves That Sleeve Gastrectomy Is Linked To Improved Glycemia In Mice

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Sleeve gastrectomy on mice

February 28, 2018

Sleeve gastrectomy (SG), a bariatric surgical procedure performed on the stomach or intestines to induce weight loss - is associated with an improvement in glycemia, via increased insulin sensitivity. Bariatric surgery dramatically improves glycemic control, yet the underlying molecular mechanisms remain controversial due to confounding weight loss.

Samir Abu Gazala, M.D., from the Hebrew University-Hadassah Medical School in Jerusalem, and colleagues, performed Sleeve Gastrectomy (SG) on obese and diabetic leptin receptor-deficient mice to examine the molecular mechanisms underlying improved glycemic control following bariatric surgery.

The researchers found that one week post-surgery mice weighed 5% less and displayed improved glycemia compared to sham-operated controls, and islets from SG mice exhibited reduced expression of diabetes markers. At one month post-surgery, SG mice weighed more than preoperatively, but remained near-euglycemic and displayed reduced hepatic lipid droplets. Pair-feeding of SG  and sham  mice showed that surgery rather than weight loss was responsible for reduced glycemia following SG. While insulin secretion profiles from islets of sham and SG mice were indistinguishable, clamp studies revealed that SG causes a dramatic improvement in muscle and hepatic insulin sensitivity, accompanied by hepatic regulation of HNF4a and PPARα targets. It was concluded that surgery, and not weight loss, was responsible for reduced glycemia following SG as indicated in pair-feeding of SG and sham db/db mice. In addition, they stated that long-term weight loss following SG requires leptin signaling, nevertheless, SG elicits a remarkable improvement in glycemia via insulin sensitization, independent of reduced feeding and weight loss.

 

Source articles:
Sleeve gastrectomy linked to improved glycemia in mice
Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity

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